A NON-OPERATIVE MANAGEMENT OF CHRONIC ANAL FISSURE.

A non-operative management of chronic anal fissure.

OBJECTIVES Assessment of efficacy of topical 0.2% glyceryl trinitrate ointment in the treatment of chronic anal fissure.PATIENTS AND METHODS A prospective study was carried out at surgical outpatient department Town Teaching Hospital from January 2017 to July 2017.Fifty consecutive patients were treated with 0.2% glyceryl trinitrate ointment and re

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Pseudomonas aeruginosa surface motility and invasion into competing communities enhance interspecies antagonism

ABSTRACT Chronic polymicrobial infections involving Pseudomonas aeruginosa and Staphylococcus aureus are prevalent, difficult to eradicate, and associated with poor health outcomes.Therefore, understanding interactions between these pathogens is important to inform improved treatment development.We previously demonstrated that P.aeruginosa is attra

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Towards Overcoming the Curse of Dimensionality: The Third-Order Adjoint Method for Sensitivity Analysis of Response-Coupled Linear Forward/Adjoint Systems, with Applications to Uncertainty Quantification and Predictive Modeling

This work presents the Third-Order Adjoint Sensitivity Analysis Methodology (3rd-ASAM) for response-coupled forward and DRESSES adjoint linear systems.The 3rd-ASAM enables the efficient computation of the exact expressions of the 3rd-order functional derivatives (“sensitivities”) of a general system response, which depends on both the f

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